Gene–Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever

Gene–Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is caused by mutations within the Mediterranean fever (MEFV) gene. Disease severity depends on genotype and gene dose with most serious clinical courses observed in patients with M694V homozygosity. Neutrophils are thought to play an important role in the initiatio...

Full description

Bibliographic Details
Main Authors: Iris Stoler, Judith Freytag, Banu Orak, Nadine Unterwalder, Stephan Henning, Katrin Heim, Horst von Bernuth, Renate Krüger, Stefan Winkler, Patience Eschenhagen, Eva Seipelt, Marcus A. Mall, Dirk Foell, Christoph Kessel, Helmut Wittkowski, Tilmann Kallinich
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
autoinflammation
familial mediterranean fever
Neutrophil
S100A12
IL-18
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00716/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00716/full

Similar Items