Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease

Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease

Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models of Huntington disease (HD). However, the invasive nature of surgical procedure and its potential to trigger the host immune response may limit its clinical use. Hence, we sought to evaluate th...

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Bibliographic Details
Main Authors: Libo Yu-Taeger, Janice Stricker-Shaver, Katrin Arnold, Patrycja Bambynek-Dziuk, Arianna Novati, Elisabeth Singer, Ali Lourhmati, Claire Fabian, Janine Magg, Olaf Riess, Matthias Schwab, Alexandra Stolzing, Lusine Danielyan, Hoa Huu Phuc Nguyen
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
Huntington disease
cell therapy
mesenchymal stem cells
intranasal
R6/2 mice
dopamine transmission
microglia
neuroinflammation
Online Access:https://www.mdpi.com/2073-4409/8/6/595

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https://www.mdpi.com/2073-4409/8/6/595

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