Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?

Objective: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate. Mouse embryonic stem cells (mESCs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mGlu5), whic...

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Bibliographic Details
Main Authors: Rokhsareh Meamar, Fereshte Karamali, Seyed Ali Mousavi, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2012-01-01
Series:Cell Journal
Subjects:
Embryonic Stem Cells
Ecstasy
MDMA
Self Renewal
mGlu Receptor
Online Access:http://celljournal.org/library/upload/article/af_22342544536222622223635735653634575342524-Meamar-1.pdf

Internet

http://celljournal.org/library/upload/article/af_22342544536222622223635735653634575342524-Meamar-1.pdf

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