Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs

Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs

Human breast cancer is characterized by a high degree of inter-patients heterogeneity in terms of histology, genomic alterations, gene expression patterns, and metastatic behavior, which deeply influences individual prognosis and treatment response. The main cause of mortality in breast cancer is th...

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Bibliographic Details
Main Authors: Simona Punzi, Marine Meliksetian, Laura Riva, Federica Marocchi, Giancarlo Pruneri, Carmen Criscitiello, Franco Orsi, Lorenzo Spaggiari, Monica Casiraghi, Paolo Della Vigna, Lucilla Luzi, Giuseppe Curigliano, Pier Giuseppe Pelicci, Luisa Lanfrancone
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
breast cancer
PDX
oncogenic alterations
personalized therapies
Online Access:https://www.mdpi.com/2073-4409/8/6/605

Internet

https://www.mdpi.com/2073-4409/8/6/605

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