Comparison between internalizing anti-HER2 mAbs and non-internalizing anti-CEA mAbs in alpha-radioimmunotherapy of small volume peritoneal carcinomatosis using 212Pb.

Comparison between internalizing anti-HER2 mAbs and non-internalizing anti-CEA mAbs in alpha-radioimmunotherapy of small volume peritoneal carcinomatosis using 212Pb.

We assessed the contribution of antibody internalization in the efficacy and toxicity of intraperitoneal α-radioimmunotherapy (RIT) of small volume carcinomatosis using (212)Pb-labeled monoclonal antibodies (mAbs) that target HER2 (internalizing) or CEA (non-internalizing) receptors.Athymic nude mic...

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Bibliographic Details
Main Authors: Vincent Boudousq, Laure Bobyk, Muriel Busson, Véronique Garambois, Marta Jarlier, Paraskevi Charalambatou, André Pèlegrin, Salomé Paillas, Nicolas Chouin, François Quenet, Patrick Maquaire, Julien Torgue, Isabelle Navarro-Teulon, Jean-Pierre Pouget
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726680?pdf=render

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http://europepmc.org/articles/PMC3726680?pdf=render

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