At Least Two Genes Encode Many Variants of Irak3 in Rainbow Trout, but Neither the Full-Length Factor Nor Its Variants Interfere Directly With the TLR-Mediated Stimulation of Inflammation

At Least Two Genes Encode Many Variants of Irak3 in Rainbow Trout, but Neither the Full-Length Factor Nor Its Variants Interfere Directly With the TLR-Mediated Stimulation of Inflammation

The interleukin-1-receptor-associated kinase 3 (IRAK3) is known in mammals as a negative feedback regulator of NF-κB-mediated innate-immune mechanisms. Our RNA-seq experiments revealed a prototypic 1920-nt sequence encoding irak3 from rainbow trout (Oncorhynchus mykiss), as well as 20 variants that...

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Bibliographic Details
Main Authors: Alexander Rebl, Henrike Rebl, Marieke Verleih, Stephanie Haupt, Judith M. Köbis, Tom Goldammer, Hans-Martin Seyfert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
CHSE-214
GFP expression plasmid
IRAK-3
salmonid fishes
Toll-like receptor signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02246/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02246/full

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