Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure
Abstract Background: Tobacco smoke exposure is an important risk factor for cardiac remodeling. Under this condition, inflammation, oxidative stress, energy metabolism abnormalities, apoptosis, and hypertrophy are present. Pentoxifylline has anti‑inflammatory, anti-apoptotic, anti-thrombotic and an...
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Sociedade Brasileira de Cardiologia (SBC)
2016-01-01
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doaj-a1e3fd73753e44a29a425256c35f43c62020-11-24T23:10:25ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41702016-01-01010.5935/abc.20160057S0066-782X2016005011101Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke ExposureMarcos MinicucciFernando OliveiraPriscila SantosBertha PolegatoMeliza RoscaniAna Angelica FernandesBeatriz LustosaSergio PaivaLeonardo ZornoffPaula AzevedoAbstract Background: Tobacco smoke exposure is an important risk factor for cardiac remodeling. Under this condition, inflammation, oxidative stress, energy metabolism abnormalities, apoptosis, and hypertrophy are present. Pentoxifylline has anti‑inflammatory, anti-apoptotic, anti-thrombotic and anti-proliferative properties. Objective: The present study tested the hypothesis that pentoxifylline would attenuate cardiac remodeling induced by smoking. Methods: Wistar rats were distributed in four groups: Control (C), Pentoxifylline (PX), Tobacco Smoke (TS), and PX-TS. After two months, echocardiography, invasive blood pressure measurement, biochemical, and histological studies were performed. The groups were compared by two-way ANOVA with a significance level of 5%. Results: TS increased left atrium diameter and area, which was attenuated by PX. In the isolated heart study, TS lowered the positive derivate (+dp/dt), and this was attenuated by PX. The antioxidants enzyme superoxide dismutase and glutathione peroxidase were decreased in the TS group; PX recovered these activities. TS increased lactate dehydrogenase (LDH) and decreased 3-hydroxyacyl Coenzyme A dehydrogenases (OH-DHA) and citrate synthase (CS). PX attenuated LDH, 3-OH-DHA and CS alterations in TS-PX group. TS increased IL-10, ICAM-1, and caspase-3. PX did not influence these variables. Conclusion: TS induced cardiac remodeling, associated with increased inflammation, oxidative stress, apoptosis, and changed energy metabolism. PX attenuated cardiac remodeling by reducing oxidative stress and improving cardiac bioenergetics, but did not act upon cardiac cytokines and apoptosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016005011101&lng=en&tlng=enPoluição por Fumaça de TabacoRemodelação VentricularPentoxifilinaEstresse OxidativoCardiomiopatias |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcos Minicucci Fernando Oliveira Priscila Santos Bertha Polegato Meliza Roscani Ana Angelica Fernandes Beatriz Lustosa Sergio Paiva Leonardo Zornoff Paula Azevedo |
spellingShingle |
Marcos Minicucci Fernando Oliveira Priscila Santos Bertha Polegato Meliza Roscani Ana Angelica Fernandes Beatriz Lustosa Sergio Paiva Leonardo Zornoff Paula Azevedo Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure Arquivos Brasileiros de Cardiologia Poluição por Fumaça de Tabaco Remodelação Ventricular Pentoxifilina Estresse Oxidativo Cardiomiopatias |
author_facet |
Marcos Minicucci Fernando Oliveira Priscila Santos Bertha Polegato Meliza Roscani Ana Angelica Fernandes Beatriz Lustosa Sergio Paiva Leonardo Zornoff Paula Azevedo |
author_sort |
Marcos Minicucci |
title |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure |
title_short |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure |
title_full |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure |
title_fullStr |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure |
title_full_unstemmed |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure |
title_sort |
pentoxifylline attenuates cardiac remodeling induced by tobacco smoke exposure |
publisher |
Sociedade Brasileira de Cardiologia (SBC) |
series |
Arquivos Brasileiros de Cardiologia |
issn |
1678-4170 |
publishDate |
2016-01-01 |
description |
Abstract Background: Tobacco smoke exposure is an important risk factor for cardiac remodeling. Under this condition, inflammation, oxidative stress, energy metabolism abnormalities, apoptosis, and hypertrophy are present. Pentoxifylline has anti‑inflammatory, anti-apoptotic, anti-thrombotic and anti-proliferative properties. Objective: The present study tested the hypothesis that pentoxifylline would attenuate cardiac remodeling induced by smoking. Methods: Wistar rats were distributed in four groups: Control (C), Pentoxifylline (PX), Tobacco Smoke (TS), and PX-TS. After two months, echocardiography, invasive blood pressure measurement, biochemical, and histological studies were performed. The groups were compared by two-way ANOVA with a significance level of 5%. Results: TS increased left atrium diameter and area, which was attenuated by PX. In the isolated heart study, TS lowered the positive derivate (+dp/dt), and this was attenuated by PX. The antioxidants enzyme superoxide dismutase and glutathione peroxidase were decreased in the TS group; PX recovered these activities. TS increased lactate dehydrogenase (LDH) and decreased 3-hydroxyacyl Coenzyme A dehydrogenases (OH-DHA) and citrate synthase (CS). PX attenuated LDH, 3-OH-DHA and CS alterations in TS-PX group. TS increased IL-10, ICAM-1, and caspase-3. PX did not influence these variables. Conclusion: TS induced cardiac remodeling, associated with increased inflammation, oxidative stress, apoptosis, and changed energy metabolism. PX attenuated cardiac remodeling by reducing oxidative stress and improving cardiac bioenergetics, but did not act upon cardiac cytokines and apoptosis. |
topic |
Poluição por Fumaça de Tabaco Remodelação Ventricular Pentoxifilina Estresse Oxidativo Cardiomiopatias |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016005011101&lng=en&tlng=en |
work_keys_str_mv |
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