Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa

Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa

Abstract Background HIV-1C has been shown to have a greater risk of virological failure and reduced susceptibility towards boosted protease inhibitors (bPIs), a component of second-line combination antiretroviral therapy (cART) in South Africa. This study entailed an evaluation of HIV-1 drug resista...

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Bibliographic Details
Main Authors: Adetayo Emmanuel Obasa, Anoop T. Ambikan, Soham Gupta, Ujjwal Neogi, Graeme Brendon Jacobs
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Infectious Diseases
Subjects:
High-throughput sequencing (HTS)
Boosted protease inhibitors (bPIs)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Nucleoside reverse transcriptase inhibitors (NRTIs)
Online Access:https://doi.org/10.1186/s12879-021-05905-2

Internet

https://doi.org/10.1186/s12879-021-05905-2

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