Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Deuterated water (2H2O) is widely used for measuring de novo lipogenesis (DNL). 2H is incorporated into fatty acids via exchange between body water and the hydrogens of acetyl-CoA, malonyl-CoA, and NADPH. Previous studies concluded that these exchanges are incomplete; therefore, fatty acid 2H enrich...

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Bibliographic Details
Main Authors: Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Lipid Research
Subjects:
pentose phosphate pathway
deuterium nuclear magnetic resonance
acetyl-coenzyme A
malonyl-coenzyme A
reduced nicotinamide adenine dinucleotide phosphate
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310439

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http://www.sciencedirect.com/science/article/pii/S0022227520310439

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