Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy*

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy*

X-linked adrenoleukodystrophy is a metabolic disorder arising from a mutation/deletion in the ABCD1 gene, leading to a defect in the peroxisomal adrenoleukodystrophy protein (ALDP), which inhibits the oxidation of very long chain fatty acids (VLCFAs). Thus, these VLCFAs accumulate. In a cerebral for...

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Bibliographic Details
Main Authors: Jaspreet Singh, Mushfiquddin Khan, Inderjit Singh
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Lipid Research
Subjects:
peroxisomes
very long chain fatty acids
glia
nitric oxide
cytokines
adrenoleukodystrophy protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414774

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http://www.sciencedirect.com/science/article/pii/S0022227520414774

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