The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis

Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to envir...

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Main Authors:	Qikun Liu, Sylvain Bischof, C. Jake Harris, Zhenhui Zhong, Lingyu Zhan, Calvin Nguyen, Andrew Rashoff, William D. Barshop, Fei Sun, Suhua Feng, Magdalena Potok, Javier Gallego-Bartolome, Jixian Zhai, James A. Wohlschlegel, Michael F. Carey, Jeffrey A. Long, Steven E. Jacobsen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16651-5

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spelling	doaj-a1f7481a95074346be1780a4740809f32021-06-06T11:16:14ZengNature Publishing GroupNature Communications2041-17232020-06-0111111310.1038/s41467-020-16651-5The characterization of Mediator 12 and 13 as conditional positive gene regulators in ArabidopsisQikun Liu0Sylvain Bischof1C. Jake Harris2Zhenhui Zhong3Lingyu Zhan4Calvin Nguyen5Andrew Rashoff6William D. Barshop7Fei Sun8Suhua Feng9Magdalena Potok10Javier Gallego-Bartolome11Jixian Zhai12James A. Wohlschlegel13Michael F. Carey14Jeffrey A. Long15Steven E. Jacobsen16School of Advanced Agricultural Sciences, Peking UniversityDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los AngelesDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesInstitute of Plant and Food Science, Department of Biology, Southern University of Science and TechnologyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los AngelesDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesDepartment of Molecular, Cell and Developmental Biology, University of California at Los AngelesMediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.https://doi.org/10.1038/s41467-020-16651-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qikun Liu Sylvain Bischof C. Jake Harris Zhenhui Zhong Lingyu Zhan Calvin Nguyen Andrew Rashoff William D. Barshop Fei Sun Suhua Feng Magdalena Potok Javier Gallego-Bartolome Jixian Zhai James A. Wohlschlegel Michael F. Carey Jeffrey A. Long Steven E. Jacobsen
spellingShingle	Qikun Liu Sylvain Bischof C. Jake Harris Zhenhui Zhong Lingyu Zhan Calvin Nguyen Andrew Rashoff William D. Barshop Fei Sun Suhua Feng Magdalena Potok Javier Gallego-Bartolome Jixian Zhai James A. Wohlschlegel Michael F. Carey Jeffrey A. Long Steven E. Jacobsen The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis Nature Communications
author_facet	Qikun Liu Sylvain Bischof C. Jake Harris Zhenhui Zhong Lingyu Zhan Calvin Nguyen Andrew Rashoff William D. Barshop Fei Sun Suhua Feng Magdalena Potok Javier Gallego-Bartolome Jixian Zhai James A. Wohlschlegel Michael F. Carey Jeffrey A. Long Steven E. Jacobsen
author_sort	Qikun Liu
title	The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
title_short	The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
title_full	The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
title_fullStr	The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
title_full_unstemmed	The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
title_sort	characterization of mediator 12 and 13 as conditional positive gene regulators in arabidopsis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.
url	https://doi.org/10.1038/s41467-020-16651-5
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The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis

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