Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability

Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability

Saposin C (sapC) is a lysosomal, peripheral-membrane protein displaying liposome fusogenic capabilities. Proteoliposomes of sapC and phosphatidylserine have been shown to be toxic for cancer cells and are currently on clinical trial to treat glioblastoma. As proof-of-concept, we show two strategies...

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Bibliographic Details
Main Authors: Suzanne I. Sandin, David M. Gravano, Christopher J. Randolph, Meenakshi Sharma, Eva de Alba
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
proteoliposomes
saposin C
PUMA
liposome fusion
glioblastoma
Online Access:https://www.mdpi.com/1999-4923/13/4/583

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https://www.mdpi.com/1999-4923/13/4/583

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