V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis

V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis

mTOR kinase is a master growth regulator that can be stimulated by multiple signals, including amino acids and the lysosomal small GTPase Rheb. Recent studies have proposed an important role for the V-ATPase in the sensing of amino acids in the lysosomal lumen. Using the Drosophila wing as a model e...

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Bibliographic Details
Main Authors: Eva Maria Gleixner, Guillaume Canaud, Tobias Hermle, Maria Clara Guida, Oliver Kretz, Martin Helmstädter, Tobias B. Huber, Stefan Eimer, Fabiola Terzi, Matias Simons
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400429X

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http://www.sciencedirect.com/science/article/pii/S221112471400429X

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