Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection

Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection

After infection with Trypanosoma cruzi, the etiologic agent of Chagas disease, immunosuppression, and apoptosis of mature lymphocytes contribute to the establishment of the parasite in the host and thereby to persistence and pathology in the chronic stage of infection. In a systemic mouse model of e...

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Bibliographic Details
Main Authors: Uwe Müller, Günter A. Schaub, Horst Mossmann, Gabriele Köhler, Rita Carsetti, Christoph Hölscher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
T. cruzi
B cell depletion
bone marrow
stromal cells
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02794/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02794/full

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