Puerarin Increases Survival and Protects Against Organ Injury by Suppressing NF-κB/JNK Signaling in Experimental Sepsis

Puerarin Increases Survival and Protects Against Organ Injury by Suppressing NF-κB/JNK Signaling in Experimental Sepsis

Puerarin, an isoflavonoid rich in Radix Puerariae, has been reported to be a broadly effective regulator in various biological processes and clinic conditions. However, the role of puerarin in sepsis-induced mortality with multiple-organ injury remains unknown. Herein, we showed that puerarin potent...

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Bibliographic Details
Main Authors: Lei Wang, Qiao Liang, Anqi Lin, Xiufang Chen, Yongzhen Wu, Bin Zhang, Yu Zhang, Haiyan Min, Yanting Wen, Shiyu Song, Qian Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
puerarin
lipopolysaccharides
sepsis
cecal ligation and puncture
liver injury
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00560/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00560/full

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