Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer

Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer

Spontaneous tumors in pet dogs represent a valuable but undercharacterized cancer model. To better use this resource, we performed an initial global comparison between proliferative and invasive colorectal tumors from 20 canine cases, and evaluated their molecular homology to human colorectal cancer...

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Bibliographic Details
Main Authors: Jin Wang, Tianfang Wang, Yanfang Sun, Yuan Feng, William C. Kisseberth, Carolyn J. Henry, Irene Mok, Susan E. Lana, Kevin Dobbin, Nicole Northrup, Elizabeth W. Howerth, Shaying Zhao
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
spontaneous canine colorectal tumors
human-dog comparison
cancer cell proliferation and gene mutations
cancer cell invasion and stromal activation
CMS4 and crypt-like or EMT invasion
Online Access:http://www.mdpi.com/2072-6694/10/9/330

Internet

http://www.mdpi.com/2072-6694/10/9/330

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