Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Melanoma is the deadliest form of skin cancer and accounts for about three quarters of all skin cancer deaths. Especially at an advanced stage, its treatment is challenging, and survival rates are very low. In previous studies, we showed that the constituents of the roots of <i>Onosma panicula...

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Bibliographic Details
Main Authors: Nadine Kretschmer, Antje Hufner, Christin Durchschein, Katrin Popodi, Beate Rinner, Birgit Lohberger, Rudolf Bauer
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
shikonin derivatives
synthesis
apoptosis
cell cycle
melanoma
Online Access:https://www.mdpi.com/1422-0067/22/5/2774

Internet

https://www.mdpi.com/1422-0067/22/5/2774

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