Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2.
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to postfusion conformation transition. Here, we rep...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-08-01
|
| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC6107290?pdf=render |