Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular biomechanics.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01667-4 |
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doaj-a21043ef77f3429eb2a9321d811b140e2021-01-31T16:16:31ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111710.1038/s42003-021-01667-4Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanicsYong Huang0Rut Tejero1Vivian K. Lee2Concetta Brusco3Theodore Hannah4Taylor B. Bertucci5Chrystian Junqueira Alves6Igor Katsyv7Michael Kluge8Ramsey Foty9Bin Zhang10Caroline C. Friedel11Guohao Dai12Hongyan Zou13Roland H. Friedel14Friedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Bioengineering, Northeastern UniversityFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Bioengineering, Northeastern UniversityFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiInstitut für Informatik, Ludwig-Maximilians-Universität MünchenDepartment of Surgery, Robert Wood Johnson Medical School, Rutgers UniversityDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiInstitut für Informatik, Ludwig-Maximilians-Universität MünchenDepartment of Bioengineering, Northeastern UniversityFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiFriedman Brain Institute, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount SinaiHuang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular biomechanics.https://doi.org/10.1038/s42003-021-01667-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yong Huang Rut Tejero Vivian K. Lee Concetta Brusco Theodore Hannah Taylor B. Bertucci Chrystian Junqueira Alves Igor Katsyv Michael Kluge Ramsey Foty Bin Zhang Caroline C. Friedel Guohao Dai Hongyan Zou Roland H. Friedel |
| spellingShingle |
Yong Huang Rut Tejero Vivian K. Lee Concetta Brusco Theodore Hannah Taylor B. Bertucci Chrystian Junqueira Alves Igor Katsyv Michael Kluge Ramsey Foty Bin Zhang Caroline C. Friedel Guohao Dai Hongyan Zou Roland H. Friedel Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics Communications Biology |
| author_facet |
Yong Huang Rut Tejero Vivian K. Lee Concetta Brusco Theodore Hannah Taylor B. Bertucci Chrystian Junqueira Alves Igor Katsyv Michael Kluge Ramsey Foty Bin Zhang Caroline C. Friedel Guohao Dai Hongyan Zou Roland H. Friedel |
| author_sort |
Yong Huang |
| title |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| title_short |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| title_full |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| title_fullStr |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| title_full_unstemmed |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| title_sort |
plexin-b2 facilitates glioblastoma infiltration by modulating cell biomechanics |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-01-01 |
| description |
Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular biomechanics. |
| url |
https://doi.org/10.1038/s42003-021-01667-4 |
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