An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events. Accordingly, assays evaluating micronucleus formation serve as useful tools within...

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Bibliographic Details
Main Authors: Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/2/344