Down-regulation of COX-2 activity by 1α,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

Down-regulation of COX-2 activity by 1α,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

Our previous reports showed that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) has antiproliferative actions in endothelial cells stably expressing viral G protein-coupled receptor (vGPCR) associated with the pathogenesis of Kaposi's sarcoma. It has been reported that COX-2 enzyme, involved in the t...

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Bibliographic Details
Main Authors: Cinthya Tapia, Fernando Zamarreño, Gabriela Alejandra Salvador, Cecilia Irene Casali, Juan Viso, María del Carmen Fernandez, John H. White, Verónica González-Pardo
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Heliyon
Subjects:
1α,25(OH)2D3
VDR
COX-2
Kaposi's sarcoma
Biocomputational method
Biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020319927

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http://www.sciencedirect.com/science/article/pii/S2405844020319927

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