Ligand chain length drives activation of lipid G protein-coupled receptors

Ligand chain length drives activation of lipid G protein-coupled receptors

Abstract Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G protein-coupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic head-group and a hydrophobic alkyl chain. This impl...

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Bibliographic Details
Main Authors: Anastassia Troupiotis-Tsaïlaki, Julian Zachmann, Inés González-Gil, Angel Gonzalez, Silvia Ortega-Gutiérrez, Maria L. López-Rodríguez, Leonardo Pardo, Cedric Govaerts
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02104-5

Internet

https://doi.org/10.1038/s41598-017-02104-5

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