Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse

The rhythmic electrical activity of the heart’s natural pacemaker, the sinoatrial node (SAN), determines cardiac beating rate (BR). SAN electrical activity is tightly controlled by multiple factors, including tissue stretch, which may contribute to adaptation of BR to changes in venous return. In mo...

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Bibliographic Details
Main Authors: Eilidh A. MacDonald, Josef Madl, Joachim Greiner, Ahmed F. Ramadan, Sarah M. Wells, Angelo G. Torrente, Peter Kohl, Eva A. Rog-Zielinska, T. Alexander Quinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00809/full