Case Report: Co-Existence of BRCA2 and PALB2 Germline Mutations in Familial Prostate Cancer With Solitary Lung Metastasis

Case Report: Co-Existence of BRCA2 and PALB2 Germline Mutations in Familial Prostate Cancer With Solitary Lung Metastasis

BackgroundMutation-caused loss-of-function of factors involved in DNA damage response (DDR) is responsible for the development and progression of ~20% of prostate cancer (PCa). Some mutations can be used in cancer risk assessment and informed treatment decisions.MethodsTarget capture-based deep sequ...

Full description

Bibliographic Details
Main Authors: Tang Tang, Lin-ang Wang, Peng Wang, Dali Tong, Gaolei Liu, Jun Zhang, Nan Dai, Yao Zhang, Gang Yuan, Kyla Geary, Dianzheng Zhang, Qiuli Liu, Jun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
BRCA2
PALB2
prostate cancer
platinum-based chemotherapy
radiotherapy
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.564694/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.564694/full

Similar Items