The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cells, and present results of genetic and pharmacolog...

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Bibliographic Details
Main Authors: Yuhua Wang, Ram Naresh Pandey, Allen J. York, Jaya Mallela, William C. Nichols, Yueh-Chiang Hu, Jeffery D. Molkentin, Kathryn A. Wikenheiser-Brokamp, Rashmi S. Hegde
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12226-1