Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images

Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images

Multiplex imaging technologies are now routinely capable of measuring more than 40 antibody-labeled parameters in single cells. However, lateral spillage of signals in densely packed tissues presents an obstacle to the assignment of high-dimensional spatial features to individual cells for accurate...

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Bibliographic Details
Main Authors: Yunhao Bai, Bokai Zhu, Xavier Rovira-Clave, Han Chen, Maxim Markovic, Chi Ngai Chan, Tung-Hung Su, David R. McIlwain, Jacob D. Estes, Leeat Keren, Garry P. Nolan, Sizun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
multiplexed tissue imaging
spatial proteomics
signal spillover
image correction
single-cell biology
cell annotation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652631/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652631/full

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