Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis.

South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysf...

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Bibliographic Details
Main Authors: Tara C Bouton, Margaretha de Vos, Elizabeth J Ragan, Laura F White, Leonie Van Zyl, Danie Theron, C Robert Horsburgh, Robin M Warren, Karen R Jacobson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223308