Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway

Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway

Abstract Background MicroRNA (miR)-containing exosomes released by acute myeloid leukemia (AML) cells can be delivered into hematopoietic progenitor cells to suppress normal hematopoiesis. Herein, our study was performed to evaluate the effect of exosomal miR-4532 secreted by AML cells on hematopoie...

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Bibliographic Details
Main Authors: Chen Zhao, Feng Du, Yang Zhao, Shanshan Wang, Ling Qi
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Acute myeloid leukemia
Exosomes
miR-4532
LDOC1
STAT3 signaling pathway
Hematopoiesis
Online Access:https://doi.org/10.1186/s13287-019-1475-7

Internet

https://doi.org/10.1186/s13287-019-1475-7

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