TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still poorly understood. Recently, proteins of the...

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Main Authors: Birte Zurek, Ida Schoultz, Andreas Neerincx, Luisa M Napolitano, Katharina Birkner, Eveline Bennek, Gernot Sellge, Maria Lerm, Germana Meroni, Johan D Söderholm, Thomas A Kufer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3400628?pdf=render

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http://europepmc.org/articles/PMC3400628?pdf=render

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