A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous “organelles” that have specific functions during the flavivirus life cycle. One of these structures is the replication complex in...

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Bibliographic Details
Main Authors: Andrea Mikulasova, Leah K. Gillespie, Rebecca L. Ambrose, Turgut E. Aktepe, Alice M. Trenerry, Susann Liebscher, Jason M. Mackenzie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
West Nile virus
RNA replication
membrane remodeling
NS4A protein
virus-host interactions
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.655606/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.655606/full

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