The Anti-ADAMTS-5 Nanobody<sup>®</sup> M6495 Protects Cartilage Degradation Ex Vivo

The Anti-ADAMTS-5 Nanobody<sup>®</sup> M6495 Protects Cartilage Degradation Ex Vivo

Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen degradation. We investigated a novel anti-ADAMTS-5 inhibiting Nanobody<sup>®</sup> (M6495) on cartilage turnover ex vi...

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Bibliographic Details
Main Authors: Anne Sofie Siebuhr, Daniela Werkmann, Anne-C. Bay-Jensen, Christian S. Thudium, Morten Asser Karsdal, Benedikte Serruys, Christoph Ladel, Martin Michaelis, Sven Lindemann
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
ADAMTS-5
aggrecan
cartilage
biomarkers
Online Access:https://www.mdpi.com/1422-0067/21/17/5992

Internet

https://www.mdpi.com/1422-0067/21/17/5992

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