Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.

Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.

BACKGROUND:Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease targeting the insulin-producing pancreatic beta cells. Naturally occurring FOXP3(+)CD4(+)CD25(high) regulatory T cells (T(regs)) play an important role in dominant tolerance, suppressing autoreactive CD4(+) effector T cell acti...

Full description

Bibliographic Details
Main Authors: Parthav Jailwala, Jill Waukau, Sanja Glisic, Srikanta Jana, Sarah Ehlenbach, Martin Hessner, Ramin Alemzadeh, Shigemi Matsuyama, Purushottam Laud, Xujing Wang, Soumitra Ghosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2716541?pdf=render

Internet

http://europepmc.org/articles/PMC2716541?pdf=render

Similar Items