The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and SK1b), increases C22:0-ceramide and diadenosine 5...

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Bibliographic Details
Main Authors: Nigel J. Pyne, Susan Pyne, David G. Watson, Robert Bittman, Evgeny Berdyshev, Irina Gorshkova, Francesca Tonelli, Viswanathan Natarajan, Manal Alossaimi
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Biomolecules
Subjects:
Sphingosine kinase inhibitors
lyso-phosphatidylinositol
sphingolipids
diadenosine 5′,5′′′-P1,P3-triphosphate
Online Access:http://www.mdpi.com/2218-273X/3/2/316

Internet

http://www.mdpi.com/2218-273X/3/2/316

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