Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might hel...

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Bibliographic Details
Main Authors: Luke Y.C. Chen, Catherine M. Biggs, Shahin Jamal, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Subjects:
cytokine storm
COVID-19
interleukin-6
interleukin-6 receptor
tocilizumab
threshold concept
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121000914

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http://www.sciencedirect.com/science/article/pii/S2666379121000914

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