Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Abstract Background A hallmark of temporal lobe epilepsy (TLE) is brain inflammation accompanied by neuronal demise. Accumulating evidence demonstrates that Rev-Erbα is involved in regulating neuroinflammation and determining the fate of neurons. Therefore, we studied the expression and cellular dis...

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Bibliographic Details
Main Authors: Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Temporal lobe epilepsy
Rev-Erbα
NLRP3 inflammasome
Neuroinflammation
Neuronal apoptosis
Online Access:https://doi.org/10.1186/s12974-020-1718-7

Internet

https://doi.org/10.1186/s12974-020-1718-7

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