Detection of Genomically Aberrant Cells within Circulating Tumor Microemboli (CTMs) Isolated from Early-Stage Breast Cancer Patients

Detection of Genomically Aberrant Cells within Circulating Tumor Microemboli (CTMs) Isolated from Early-Stage Breast Cancer Patients

Circulating tumor microemboli (CTMs) are clusters of cancer cells detached from solid tumors, whose study can reveal mechanisms underlying metastatization. As they frequently comprise unknown fractions of leukocytes, the analysis of copy number alterations (CNAs) is challenging. To address this, we...

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Bibliographic Details
Main Authors: Marco Silvestri, Carolina Reduzzi, Giancarlo Feliciello, Marta Vismara, Thomas Schamberger, Cäcilia Köstler, Rosita Motta, Stefano Calza, Cristina Ferraris, Andrea Vingiani, Giancarlo Pruneri, Maria Grazia Daidone, Christoph A. Klein, Bernhard Polzer, Vera Cappelletti
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
breast cancer
circulating tumor microemboli
metastatic dissemination
tumor fraction
copy number alteration
low-pass whole genome sequencing
Online Access:https://www.mdpi.com/2072-6694/13/6/1409

Internet

https://www.mdpi.com/2072-6694/13/6/1409

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