Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

Abstract Background Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propi...

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Bibliographic Details
Main Authors: Yang Zhang, Xiuling Zhou, Xuemei Wang, Lu Wang, Menglei Xia, Jianmei Luo, Yanbing Shen, Min Wang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Microbial Cell Factories
Subjects:
Mycobacterium neoaurum
Androstenedione
Methylcitrate cycle
Transcriptional regulator
Nitrogen level
Online Access:https://doi.org/10.1186/s12934-020-1285-8

Internet

https://doi.org/10.1186/s12934-020-1285-8

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