Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models

Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models

Abstract Background Before the deposition of amyloid-beta plaques and the onset of learning memory deficits, patients with Alzheimer’s disease (AD) experience olfactory dysfunction, typified by a reduced ability to detect, discriminate, and identify odors. Rodent models of AD, such as the Tg2576 and...

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Bibliographic Details
Main Authors: Ming Chen, Yunan Chen, Qingwei Huo, Lei Wang, Shuyi Tan, Afzal Misrani, Jinxiang Jiang, Jian Chen, Shiyuan Chen, Jiawei Zhang, Sidra Tabassum, Jichen Wang, Xi Chen, Cheng Long, Li Yang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
APP/PS1
3xTg
Olfactory bulb
Gamma oscillations
GABAAR
Online Access:https://doi.org/10.1186/s13024-021-00434-7

Internet

https://doi.org/10.1186/s13024-021-00434-7

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