Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3

Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3

Abstract Background Emerging evidence suggests that microRNAs (miRs) are associated with the progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived from mesenchymal stem cells (MSCs) in OA progression is investigated and the potential therapeutic mechanism explore...

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Bibliographic Details
Main Authors: Xue Chen, Yuanyuan Shi, Pan Xue, Xinli Ma, Junfeng Li, Jun Zhang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Arthritis Research & Therapy
Subjects:
Traumatic osteoarthritis
Chondrocyte degeneration
Bone marrow mesenchymal stem cells
Exosome
microRNA-136-5p
ELF3
Online Access:http://link.springer.com/article/10.1186/s13075-020-02325-6

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http://link.springer.com/article/10.1186/s13075-020-02325-6

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