In Silico Screening and Designing Synthesis of Cinchona Alkaloids Derivatives as Potential Anticancer
P-glycoprotein (P-gp) resistance in cancer cells decreases intracellular accumulation of various anticancer drugs. This multidrug resistance (MDR) protein can be modulated by a number of non-cytotoxic drugs. We have screened 30 chincona alkaloids derivatives as a potent P-gp inhibitor agent in silic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Brawijaya
2017-06-01
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| Series: | Journal of Tropical Life Science |
| Subjects: | |
| Online Access: | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/662 |