Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

Abstract Background Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, a dipeptidyl peptidase-4 inhibitor, improved DD in Zucker Obese rats, a...

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Bibliographic Details
Main Authors: Annayya R. Aroor, Javad Habibi, Hemanth Kumar Kandikattu, Mona Garro-Kacher, Brady Barron, Dongqing Chen, Melvin R. Hayden, Adam Whaley-Connell, Shawn B. Bender, Thomas Klein, Jaume Padilla, James R. Sowers, Bysani Chandrasekar, Vincent G. DeMarco
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cardiovascular Diabetology
Subjects:
Diastolic dysfunction
Myocardial fibrosis
Obesity
TRAF3IP2
Linagliptin
Online Access:http://link.springer.com/article/10.1186/s12933-017-0544-4

Internet

http://link.springer.com/article/10.1186/s12933-017-0544-4

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