Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes

Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes

(1) Background: Abnormal accumulation of extracellular glutamate can occur as dysfunction of astrocytic glutamate transporters, which has been linked to ischemic brain injury. Excessive extracellular glutamate-induced abnormal excitotoxicity is the major cause of secondary neuronal damage after cere...

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Bibliographic Details
Main Authors: Chia-Ho Lin, Han-Yu Chen, Kai-Che Wei
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
astrocyte
glutamate reuptake
high-mobility group box 1
ischemic stroke
oxygen-glucose deprivation/reoxygenation
toll-like receptor 4
Online Access:https://www.mdpi.com/2073-4409/9/12/2585

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https://www.mdpi.com/2073-4409/9/12/2585

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