PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

Abstract Background Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated macrophages (TAMs) polarization in colon cancer has never been reporte...

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Bibliographic Details
Main Authors: Yang Cheng, Yun Zhu, Jiajia Xu, Min Yang, Peiyu Chen, Wanfu Xu, Junhong Zhao, Lanlan Geng, Sitang Gong
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cancer
Subjects:
PKN2
Colon cancer
Macrophage polarization
Erk1/2
DUSP6
Online Access:http://link.springer.com/article/10.1186/s12943-017-0747-z

Internet

http://link.springer.com/article/10.1186/s12943-017-0747-z

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