Hirschsprung´s Disease—Recent Understanding of Embryonic Aspects, Etiopathogenesis and Future Treatment Avenues

Hirschsprung´s disease is a neurocristopathy, caused by defective migration, proliferation, differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually manifests rapidly after birth, affecting 1 in 5000 live births around the globe. In recent decades, there has been...

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Bibliographic Details
Main Authors: Martin Klein, Ivan Varga
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Medicina
Subjects:
Online Access:https://www.mdpi.com/1010-660X/56/11/611