Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononu...

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Bibliographic Details
Main Authors: Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
peripheral blood mononuclear cells
polyunsaturated fatty acids
desaturase
elongase
DNA methylation
cell proliferation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00432/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00432/full

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