Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Abstract Background The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important pathophysiological process contributing to the development of nephrolith...

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Bibliographic Details
Main Authors: Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Translational Medicine
Subjects:
Androgen
Testosterone
Kidney
Tubular epithelial cell
BNIP3
Cell death
Online Access:http://link.springer.com/article/10.1186/s12967-019-1821-7

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http://link.springer.com/article/10.1186/s12967-019-1821-7

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