A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain

Voltage-gated sodium channel Nav1.9 is a threshold channel that regulates action potential firing. Nav1.9 is preferentially expressed in myenteric neurons, and small-diameter dorsal root ganglion (DRG) and trigeminal ganglion neurons including nociceptors. Recent studies have demonstrated a monogeni...

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Bibliographic Details
Main Authors: Jianying Huang, Mark Estacion, Peng Zhao, Fadia B. Dib-Hajj, Betsy Schulman, Angela Abicht, Ingo Kurth, Knut Brockmann, Stephen G. Waxman, Sulayman D. Dib-Hajj
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
channelopathy
DRG
pain
sodium channel
SCN11A
excitability
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00918/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00918/full

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