Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal...

Full description

Bibliographic Details
Main Authors: Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak
Format: Article
Language:English
Published: The Company of Biologists 2021-08-01
Series:Disease Models & Mechanisms
Subjects:
apol1
kidney
mouse
transgenic
Online Access:http://dmm.biologists.org/content/14/8/dmm048952

Internet

http://dmm.biologists.org/content/14/8/dmm048952

Similar Items