Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment

Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment

Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited efficacy and are associated with significant side effects. There is therefore the need for new protolerogenic treatments to replace CS. D...

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Bibliographic Details
Main Authors: Laure-Hélène Ouisse, Séverine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, Lucas Brusselle, Nadège Vimond, Karl Rouger, Yann Péréon, Alexis Chenouard, Christèle Gras-Le Guen, Cécile Braudeau, Régis Josien, Corinne Huchet, Ignacio Anegon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Treg
tolerance
muscle injury
dystrophin
immunosuppression
knockout rats
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02131/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02131/full

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