Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.

Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.

The murine model of T. cruzi infection has provided compelling evidence that development of host resistance against intracellular protozoans critically depends on the activation of members of the Toll-like receptor (TLR) family via the MyD88 adaptor molecule. However, the possibility that TLR/MyD88...

Full description

Bibliographic Details
Main Authors: Ana-Carolina Oliveira, Bruna C de Alencar, Fanny Tzelepis, Weberton Klezewsky, Raquel N da Silva, Fabieni S Neves, Gisele S Cavalcanti, Silvia Boscardin, Marise P Nunes, Marcelo F Santiago, Alberto Nóbrega, Maurício M Rodrigues, Maria Bellio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2861687?pdf=render

Internet

http://europepmc.org/articles/PMC2861687?pdf=render

Similar Items